PEA for Chronic Pain

🌿 PEA & Pain: Replenishing the Body’s Natural Defense

Palmitoylethanolamide (PEA) is a fatty acid amide naturally produced by our cells to help regulate pain and inflammation. It belongs to the endocannabinoid family, a group of lipid messengers that play a key role in maintaining balance and calm within the body’s nervous and immune systems.

PEA is part of the body’s quiet defense system — a molecule of comfort working behind the scenes to restore equilibrium. But when pain becomes chronic, this system can falter.

• PEA exhaustion may occur when the body’s natural supply is depleted by prolonged pain or inflammation

• Chronic inflammatory conditions are often linked to lower endogenous PEA levels

• Supplementing with PEA may help replenish what’s lost, restoring its protective, anti-inflammatory, and analgesic effects

• In rare cases, hypoalgesia (a high pain threshold) can result from an inability to break down PEA and similar fatty acid compounds

• Clinical studies show that PEA may reduce symptoms of neuropathic pain, including burning pain, pressing pain, and numbness associated with pain — offering relief in conditions such as postherpetic neuralgia and chemotherapy-induced neuropathy.

By supporting the body’s own healing mechanisms, exogenous PEA offers a gentle yet powerful way to reawaken resilience — especially for those navigating long-term pain.